More GUTLESS COWARD BS by a GUTLESS COWARD who will NEVER address an issue just the TreasonMonkey two step lookover THERE or over THERE or over THERE BUT BUT BUT BUT BUT flitting from IGNORANT BRAINWASHED TALKING point to IGNORANT BRAINWASHED talking point while RUNNING AWAY like the GUTLESS COWARD YOU ARE
I could CRUSH this too but why bother just to have you RUN to a different talking point you GUTLESS COWARD. This thead has a TOPIC GUTLESS COWARD one you keep RUNNING FROM like a GUTLESS COWARD
https://www.nature.com/articles/d41586-021-02081-w
Flawed ivermectin preprint highlights challenges of COVID drug studies
Throughout the pandemic, the anti-parasite drug ivermectin has attracted much attention, particularly in Latin America, as a potential way to treat COVID-19. But scientists say that recent, shocking revelations of widespread flaws in the data of a preprint study reporting that the medication greatly reduces COVID-19 deaths dampens ivermectin’s promise — and highlights the challenges of investigating drug efficacy during a pandemic.
“I was shocked, as everyone in the scientific community probably were,” says Eduardo López-Medina, a paediatrician at the Centre for the Study of Paediatric Infections in Cali, Colombia, who was not involved with the study and who has investigated whether ivermectin can improve COVID-19 symptoms. “It was one of the first papers that led everyone to get into the idea ivermectin worked” in a clinical-trial setting, he adds.
https://ebm.bmj.com/content/early/2021/ ... 021-111678
Misleading clinical evidence and systematic reviews on ivermectin for COVID-19
Ivermectin is a broad-spectrum antiparasitic agent approved by the Food and Drug Administration (FDA) of the USA proved to be safe at the conventional dose of ≤200 µg/kg, although severe adverse effects ranging from ataxia to seizures have occasionally been reported.5 And due to its in vitro antiviral activity against a broad range of viruses, it has been used off-label for the treatment of some viral diseases.13 17
In a vertiginous search for COVID-19 treatments, Caly et al conducted an in vitro exploration that showed ivermectin’s inhibitor role on the replication of the SARS-CoV-2 virus,17 18 among few other in silico and in vitro results suggesting the same.19–21 Thus, a considerable amount of preprints and protocol records quickly appeared, reporting the clinical efficacy of ivermectin in standard doses for COVID-19. The dissemination of these results caused confusion, and the general population and some clinicians endorsed the use of ivermectin, especially in Latin America.22 However, in a matter of days since the publication of Caly et al17 and its repercussions, a general publication from the Pan American Health Organization (PAHO) stated that “…ivermectin is incorrectly being used for the treatment of COVID-19, without any scientific evidence of its efficacy and safety for the treatment of this disease.”23
An important controversial point to consider in any rationale is the 5 µM required concentration to reach the anti-SARS-CoV-2 action of ivermectin observed in vitro,17 which is much higher than 0.28 µM, the maximum reported plasma concentration achieved in vivo with a dose of approximately 1700 µg/kg (about nine times the FDA-approved dosification).24 25 In this sense, basic fundamentals for assessing ivermectin in COVID-19 at a clinical level appear to be insufficient. Among other reasons, we believe this might have led WHO to exclude ivermectin from its Solidarity Trial for repurposed drugs for COVID-19,12 which raises questions about the pertinence of conducting clinical studies on ivermectin.
https://www.nytimes.com/2021/03/04/scie ... tment.html
https://www.yahoo.com/now/column-major- ... 51048.html
Column: Major study of Ivermectin, the anti-vaccine crowd's latest COVID drug, finds 'no effect whatsoever'
I've had enough abuse and so have the other clinical trialists doing Ivermectin. Others working in this area have been threatened, their families have been threatened, they've been defamed.
Edward Mills, COVID researcher
Among the 1,500 patients in the study, he said, Ivermectin showed "no effect whatsoever" on the trial's outcome goals — whether patients required extended observation in the emergency room or hospitalization.
"In our specific trial," he said, "we do not see the treatment benefit that a lot of the advocates believe should have been" seen.