17 Jul 2022 9:05 am
"Pharmacol Res. 2021 Jan; 163: 105207.
Published online 2020 Sep 21. doi: 10.1016/j.phrs.2020.105207
PMCID: PMC7505114
PMID: 32971268
Ivermectin, a potential anticancer drug derived from an antiparasitic drug
Mingyang Tang,a,b,1 Xiaodong Hu,c,1 Yi Wang,a,d Xin Yao,a,d Wei Zhang,a,b Chenying Yu,a,b Fuying Cheng,a,b Jiangyan Li,a,d and Qiang Fanga,d,e,*
Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells. This may be related to the regulation of multiple signaling pathways by ivermectin through PAK1 kinase. On the other hand, ivermectin promotes programmed cancer cell death, including apoptosis, autophagy and pyroptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Interestingly, ivermectin can also inhibit tumor stem cells and reverse multidrug resistance and exerts the optimal effect when used in combination with other chemotherapy drugs."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505114/figure/fig0030/?report=objectonly
Ivermectin treatment is a ‘real killer of coronavirus’ - a "wonder drug"