17 Sep 2023 11:25 am
COVID-19 and hydroxychloroquine
Edit
Hydroxychloroquine was an early failed experimental treatment for COVID-19.[49] It is not effective for preventing infection.[52][53][54][55][56] Several countries initially used chloroquine or hydroxychloroquine for treatment of persons hospitalized with COVID‑19, and from April to June 2020, there was an emergency use authorization (EUA) for its use in the United States,[57] and was used off label for potential treatment of the disease.[58] On 24 April 2020, citing the risk of "serious heart rhythm problems", the FDA posted a caution against using the drug for COVID‑19 "outside of the hospital setting or a clinical trial".[59]
In June, hydroxychloroquine proved to have no benefit for hospitalized patients with severe COVID-19 illness in the international Solidarity trial and UK RECOVERY Trial.[60][61] On 15 June, the FDA revoked a previously-granted EUA, stating that it was "no longer reasonable to believe" that the drug was effective against COVID-19 or that its benefits outweighed "known and potential risks".[62][63]
In the same month, AAPS filed a lawsuit against the Food and Drug Administration to "end its arbitrary interference with the use of hydroxychloroquine (HCQ)."[64][65] The group's position was used to justify President Donald Trump taking HCQ as protection against COVID-19 by his campaign manager Brad Parscale.[66] Several AAPS members and supporters went on the record advocating for HCQ as an effective treatment against COVID-19, led by Ukrainian-American physician Vladimir Zelenko with a three-drug regimen of off-label hydroxychloroquine, zinc, and Azithromycin as part of an experimental outpatient treatment for COVID-19 that became known as the Zelenko Protocol.[67] Early in the pandemic, the experimental treatment had received broad recognition from Sean Hannity, Rudy Giuliani, and Mark Meadows, elevating Zelenko to minor celebrity status in conservative political circles.[68] Other prominent AAPS-affiliated advocates include Simone Gold of America's Frontline Doctors,[69] Niran Al-Agba of Physicians for Patient Protection,[70] and former AAPS president Marilyn Singleton.
Edit
Hydroxychloroquine was an early failed experimental treatment for COVID-19.[49] It is not effective for preventing infection.[52][53][54][55][56] Several countries initially used chloroquine or hydroxychloroquine for treatment of persons hospitalized with COVID‑19, and from April to June 2020, there was an emergency use authorization (EUA) for its use in the United States,[57] and was used off label for potential treatment of the disease.[58] On 24 April 2020, citing the risk of "serious heart rhythm problems", the FDA posted a caution against using the drug for COVID‑19 "outside of the hospital setting or a clinical trial".[59]
In June, hydroxychloroquine proved to have no benefit for hospitalized patients with severe COVID-19 illness in the international Solidarity trial and UK RECOVERY Trial.[60][61] On 15 June, the FDA revoked a previously-granted EUA, stating that it was "no longer reasonable to believe" that the drug was effective against COVID-19 or that its benefits outweighed "known and potential risks".[62][63]
In the same month, AAPS filed a lawsuit against the Food and Drug Administration to "end its arbitrary interference with the use of hydroxychloroquine (HCQ)."[64][65] The group's position was used to justify President Donald Trump taking HCQ as protection against COVID-19 by his campaign manager Brad Parscale.[66] Several AAPS members and supporters went on the record advocating for HCQ as an effective treatment against COVID-19, led by Ukrainian-American physician Vladimir Zelenko with a three-drug regimen of off-label hydroxychloroquine, zinc, and Azithromycin as part of an experimental outpatient treatment for COVID-19 that became known as the Zelenko Protocol.[67] Early in the pandemic, the experimental treatment had received broad recognition from Sean Hannity, Rudy Giuliani, and Mark Meadows, elevating Zelenko to minor celebrity status in conservative political circles.[68] Other prominent AAPS-affiliated advocates include Simone Gold of America's Frontline Doctors,[69] Niran Al-Agba of Physicians for Patient Protection,[70] and former AAPS president Marilyn Singleton.