In vivo, Ivermectin alone is more effective than standard chemotherapy (gemcitabine) alone at reducing tumor weight and volume in pancreatic cancer (Lee, et al., 2022)... In cases successfully treated with a total or partial combination of Ivermectin, dichloroacetate, and Omeprazole (plus Tamoxifen), Ivermectin inhibited tumor growth through mitochondrial dysfunction and led to apoptosis (Ishiguro, et al., 2022).