Apparently, they have been shooting them down fairly frequently:
In 2015, a record number (20) of USAF drones crashed; investigators identified three parts of the starter-generator that were susceptible to breakdowns, but could not determine why they were failing. Col. William S. Leister informed Pentagon officials that investigators from the USAF, General Atomics and Skurka had investigated the problem for more than a year. The team, he said, had identified "numerous manufacturing quality issues" yet had been unable to determine the exact cause of the failures.
On
2 October 2017, an MQ-9 had been shot down by HouthiS air defense systems over Saana in western Yemen the previous day.
On
6 June 2019, Houthis shot down a US MQ-9 Reaper over Yemen.
On
21 August 2019, another unarmed MQ-9 was shot down by Houthis over Dhamar, Yemen,
[76] by a Yemini made Fater-1 missile, an improved SA-6.
On
23 November 2019, a US MQ-9 Reaper was shot down by a
Pantsir system operated by the
Libyan National Army or
Wagner Group over
Tripoli, Libya.
On
18 August 2020, two US MQ-9 Reapers had crashed in a
mid-air collision over Syria. However, claims from local media said that at least one drone might have been shot down by
Syrian Opposition rebel fighters or Turkish forces.
On
14 July 2022, a MQ-9 Reaper crashed during a training mission in Romania.
On
14 March 2023, one of two intercepting
Su-27 fighters of the Russian Federation
collided with an MQ-9 Reaper flying in international airspace over the Black Sea.