Liberal Forum

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Risks of high-dose aspirin

Generally, high-dose aspirin is not recommended during pregnancy due to the following risks: 

• First trimester: High doses may increase the risk of miscarriage and have been linked to a higher risk of birth defects. Some older studies also suggested a possible link to gastroschisis, a defect where a baby's intestines grow outside the body. However, more recent research has yielded inconsistent findings regarding gastroschisis and other malformations during the first trimester.
• Second trimester (after 19 weeks): The FDA advises against taking high-dose aspirin after 19 weeks because it can cause rare but serious kidney problems in the fetus. This can lead to low amniotic fluid and other complications.
• Third trimester: High doses increase the risk of a fetal heart vessel, the ductus arteriosus, closing prematurely. This can cause the baby to develop pulmonary hypertension. Long-term use in the third trimester also increases the risk of bleeding in the brain for premature infants. 

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////////////First trimester. During the first trimester, higher doses of aspirin may raise the risk of pregnancy loss. Taking a high dose also could raise the risk of a baby having medical conditions present at birth, called congenital defects.
Second trimester. The U.S. Food and Drug Administration, also known as the FDA, advises pregnant people not to take aspirin, ibuprofen (Advil, Motrin IB, others) or naproxen sodium (Aleve) after 19 weeks of pregnancy. Taking these medicines could cause rare but serious kidney conditions in a fetus. That can lead to low levels of amniotic fluid. And that can cause more problems for the fetus.//////////////////////

https://www.mayoclinic.org/healthy-life ... q-20058167